Many patients have no or minimal symptoms related to the tumor , and their metastases are found during a routine medical evaluation. If there are symptoms, they depend on the site involved. • Brain metastases may cause headaches, dizziness, blurred vision, nausea or other symptoms related to the nervous system. • Bone metastases may be evident because of pain, although they frequently cause no symptoms. The first sign of a bone metastasis may be when the affected bone breaks, often after a minor injury or no injury at all. • Lung metastases may cause a non-productive cough, or a cough producing bloody sputum , chest pain or shortness of breath. • Liver metastases may cause weight loss, fevers, nausea, loss of appetite, abdominal pain, fluid in the abdomen or jaundice (the skin turning yellow).